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Nikolay Solovyev

Associate Prof., Ph.D. (Chem.)

Mail address: 198504, Russia, Saint Petersburg, Peterhof, Universitetsky pr, 26, Institute of Chemistry, Department of Analytical Chemistry
Laboratory №: 3095
e-mail: n.solovyev@spbu.ru
 ResearcherID B-8100-2013
AuthorID 36509331800
SPIN 70375046
ORCID 0000-0002-6217-6963

Scientific-and-educational group:
methods of mass-spectral analysis

Scientific achievements:
Primary research area is related to methodological work in the field of elemental analysis – development of methods and analysis of schemes based upon inorganic and molecular mass spectrometry as well as atomic absorption and atomic emission spectrometry, methodology and practical application of the trace elements speciation for the study of transport and metabolism of minerals, as well as their role in the etiology and pathogenesis of various diseases. Another important area of work is connected with metalodrugs research, including pharmacokinetics, efficacy testing, etc.

Main results of applied work:
Control methods of Federal medico-biological agency:
1. МУК 4.1.030-15 “Guidelines on methods of control. Method of measuring the mass of thallium concentrations in human blood samples by atomic absorption method”, Federal Medico-Biological Agency, Moscow, 2015, 28 p.
2. МУК 4.1.031-15 “Guidelines on methods of control. Method of measurement of mass concentration of selenium in human blood samples by atomic absorption method with electrothermal atomization”, Federal Medico-Biological Agency, Moscow, 2015, 27 p. [
3. МУК 4.1.032-15 “Guidelines on methods of control. Method of measurement of mass concentration of lead in human blood samples by atomic absorption method with electrothermal atomization”, Federal Medico-Biological Agency, Moscow, 2015, 26 p.
4. МУК 4.1.033-15 “Guidelines on methods of control. Method of measuring of mass concentration of manganese, aluminum, chromium and titanium in the blood and human plasma by atomic absorption method”, Federal Medico-Biological Agency, Moscow, 2015, 26 p.
5. МУК 4.1.034-15 “Guidelines on methods of control. Method of measurement of mass concentration of nickel in human blood samples by atomic absorption method with electrothermal atomization”, Federal Medico-Biological Agency, Moscow, 2015, 27 p.
6. МУК 4.1.035-15 “Guidelines on methods of control. Method of measurement of mass concentration of beryllium in human blood samples by atomic absorption method with electrothermal atomization”, Federal Medico-Biological Agency, Moscow, 2015, 27 p.
7. МУК 4.1.036-15 “Guidelines on methods of control. Method of measurement of mass concentration of cadmium in human blood samples by atomic absorption method”, Federal Medico-Biological Agency, Moscow, 2015, 28 p.

Educational job:

  • Teaching courses:
    Analytical Chemistry I: Chemical Methods of Analysis (bachelor’s program “Chemistry, Physics and Mechanics of Materials”, 2 year)
    Analytical Chemistry II: Physicochemical Methods of Analysis (bachelor’s program “Chemistry”, 2 year)
    Ecological Chemistry (bachelor’s program “Chemistry”, 3 year)
    Chemistry (bachelor’s program “Geology”,1 year)
    Chemistry ((bachelor’s program “Soil sciences”, 1 year)

Publications:

  1. Drobyshev E.J., Solovyev N.D., Ivanenko N.B., Kombarova M.Y., Ganeev A.A. 2017. Trace element biomonitoring in hair of school children from a polluted area by sector field inductively coupled plasma mass spectrometry. Journal of Trace Elements in Medicine and Biology 39:14-20. DOI: 10.1016/j.jtemb.2016.07.004.
  2. Ganeev A., Gubal A., Korotetski B., Bogdanova O., Burakov B., Titova A., Solovyev N., Ivanenko N., Drobyshev E., Iakovleva E., Sillanpää M. 2017. Direct isotope analysis of Chernobyl microparticles using time-of-flight mass spectrometry with pulsed glow discharge. Microchemical Journal 132:286-292. DOI: 10.1016/j.microc.2017.02.015.
  3. Mandrioli J., Michalke B., Solovyev N., Grill P., Violi F., Lunetta C., Conte A., Sansone V.A., Sabatelli M., Vinceti M. 2017. Elevated Levels of Selenium Species in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients with Disease-Associated Gene Mutations. Neurodegenerative Diseases 17:171-180. DOI: 10.1159/000460253.
  4. Michalke B., Willkommen D., Drobyshev E., Solovyev N. 2017. The importance of speciation analysis in neurodegeneration research. TrAC – Trends in Analytical Chemistry, 10.1016/j.trac.2017.08.008.
  5. Solovyev N., Vinceti M., Grill P., Mandrioli J., Michalke B. 2017. Redox speciation of iron, manganese, and copper in cerebrospinal fluid by strong cation exchange chromatography – sector field inductively coupled plasma mass spectrometry. Analytica Chimica Acta 973:25-33. DOI: 10.1016/j.aca.2017.03.040.
  6. Solovyev N.D., Fedoros E.I., Drobyshev E.J., Ivanenko N.B., Pigarev S.E., Tyndyk M.L., Anisimov V.N., Vilpan Y.A., Panchenko A.V. 2017. Anticancer activity and tissue distribution of platinum (II) complex with lignin-derived polymer of benzene-poly-carboxylic acids. Journal of Trace Elements in Medicine and Biology 43:72-79. DOI: 10.1016/j.jtemb.2016.11.009.
  7. Zubakina E.A., Solovyev N.D., Savinkova E.S., Slesar N.I. 2016. Sample preparation for cadmium quantification in sunflower (Heliánthus ánnuus) seeds using anodic stripping voltammetry. Analytical Methods 8:326-332. DOI: 10.1039/c5ay02275d.
  8. Ganeev A., Bogdanova O., Ivanov I., Burakov B., Agafonova N., Korotetski B., Gubal A., Solovyev N., Iakovleva E., Sillanpää M. 2015. Direct determination of uranium and thorium in minerals by time-of-flight mass spectrometry with pulsed glow discharge. RSC Advances 5:80901-80910. DOI: 10.1039/c5ra13312b.
  9. Navolotskii D.V., Ivanenko N.B., Solovyev N.D., Fedoros E.I., Panchenko A.V. 2015. Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP-C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry. Drug Testing and Analysis 7:737-744. DOI: 10.1002/dta.1824.
  10. Solovyev N.D. 2015. Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. Journal of Inorganic Biochemistry 153:1-12. DOI: 10.1016/j.jinorgbio.2015.09.003.
  11. Ivanenko N.B., Ivanenko A.A., Solovyev N.D., Navolotskii D.V., Pavlova O.V., Ganeev A.A. 2014. Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion. Biomeditsinskaya Khimiya 60:378-388.
  12. Ivanenko N.B., Solovyev N.D., Ivanenko A.A., Navolotskii D.V. 2014. Biological monitoring of arsenic pollution based on whole blood arsenic atomic absorption assessment with in situ hydride trapping. Journal of Analytical Atomic Spectrometry 29:1850-1857. DOI: 10.1039/c4ja00130c.
  13. Ivanenko N.B., Ivanenko A.A., Solovyev N.D., Zeimal A.E., Navolotskii D.V., Drobyshev E.J. 2013. Biomonitoring of 20 trace elements in blood and urine of occupationally exposed workers by sector field inductively coupled plasma mass spectrometry. Talanta 116:764-769. DOI: 10.1016/j.talanta.2013.07.079.
  14. Solovyev N., Berthele A., Michalke B. 2013. Selenium speciation in paired serum and cerebrospinal fluid samples. Analytical and Bioanalytical Chemistry 405:1875-1884. DOI: 10.1007/s00216-012-6294-y.
  15. Vinceti M., Solovyev N., Mandrioli J., Crespi C.M., Bonvicini F., Arcolin E., Georgoulopoulou E., Michalke B. 2013. Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite. NeuroToxicology 38:25-32. DOI: 10.1016/j.neuro.2013.05.016.
  16. Ivanenko N.B., Solovyev N.D., Ivanenko A.A., Ganeev A.A. 2012. Application of zeeman graphite furnace atomic absorption spectrometry with high-frequency modulation polarization for the direct determination of aluminum, beryllium, cadmium, chromium, mercury, manganese, nickel, lead, and thallium in human blood. Archives of Environmental Contamination and Toxicology 63:299-308. DOI: 10.1007/s00244-012-9784-1.
  17. Ivanenko N.B., Ganeev A.A., Solovyev N.D., Moskvin L.N. 2011. Determination of trace elements in biological fluids. Journal of Analytical Chemistry 66:784-799. DOI: 10.1134/S1061934811090036.
  18. Solovyev N.D., Ivanenko N.B., Ivanenko A.A. 2011. Whole blood thallium determination by GFAAS with high-frequency modulation polarization Zeeman effect background correction. Biological Trace Element Research 143:591-599. DOI: 10.1007/s12011-010-8865-0.

Scholarships and grants:
1) 2016 – 2018 The project of the Russian Foundation of Basic Research No. 16-33-60004 mol_a_dk (primary investigator) “Metalloproteins and low molecular mass species of selenium, copper and manganese in etiology of neurodegenerative disease”.
2) 2015 “Dmitrij Mendeleev” joint programme SPbSU – DAAD (primary investigator), “Selenium species and human neurodegeneration”.
3) 2017, «Copper speciation and high accuracy analysis in the diagnosis of Wilson’s disease», RSC Researcher mobility grant, (Primary investigator).
4) 2017 “Dmitrij Mendeleev” joint programme SPbSU – DAAD (primary investigator) “Non-targeted metabolomics and diagnostic biomarkers of neurodegenerative states in human “.

Public and organizing activity:
Member of Royal Society of Chemistry
Member of the German Society of Minerals and Trace Elements (Gesellschaft für Mineralstoffe und Spurenelemente – GMS)
Organisation committee member for the X International young scientist conference on Chemistry «Mendeleev-2017», St. Petersburg, April 2017
Organisation committee member for the 4th International Symposium on Trace Elements and Minerals in Medicine and Biology, St. Petersburg, June 2010

Research awards and honors:
2017 Heinz Zumkley Prize for the young researcher in the field of trace elements and minerals from the German Society of Trace elements and minerals.
Editorial board member – Journal of Trace Elements in Medicine and Biology.