Methods of mass-spectral analysis

Mail address: 198504, Russia, Saint Petersburg, Peterhof, Universitetsky pr, 26, Institute of Chemistry, Department of Analytical Chemistry
Laboratory №: 3095, 3096

Group members:
Nikolay Solovyev, associate prof., PhD

Anna Gubal, junior researcher, PhD

Yaroslav Dubrovskii, researcher, PhD

Students and PhD-students:

Victoria Bodnar, PhD student, 1 year
Ilya Gorbunov, master student, 1 year
Lyalkin Yegor, bachelor student, 3 year

Area of research:
Research and development in inorganic mass spectrometry
Speciation analysis, metallomics and metabolomics
Proteomics, metalloproteomics and protein post-translational modification
Determination of trace elements in biological fluids and tissues, environmental objects and foodstuffs
Bioanalytical chemistry and biomarkers


  1. Drobyshev E.J., Solovyev N.D., Ivanenko N.B., Kombarova M.Y., Ganeev A.A. 2017. Trace element biomonitoring in hair of school children from a polluted area by sector field inductively coupled plasma mass spectrometry. Journal of Trace Elements in Medicine and Biology 39:14-20. DOI: 10.1016/j.jtemb.2016.07.004.
  2. Ganeev A., Gubal A., Korotetski B., Bogdanova O., Burakov B., Titova A., Solovyev N., Ivanenko N., Drobyshev E., Iakovleva E., Sillanpää M. 2017. Direct isotope analysis of Chernobyl microparticles using time-of-flight mass spectrometry with pulsed glow discharge. Microchemical Journal 132:286-292. DOI: 10.1016/j.microc.2017.02.015.
  3. Gubal A., Ganeev A., Hoffmann V., Voronov M., Brackmann V., Oswald S. 2017. Combined hollow cathode: Vs. Grimm cell: Semiconductive and nonconductive samples. Journal of Analytical Atomic Spectrometry 32:354-366. DOI: 10.1039/c6ja00324a.
  4. Mandrioli J., Michalke B., Solovyev N., Grill P., Violi F., Lunetta C., Conte A., Sansone V.A., Sabatelli M., Vinceti M. 2017. Elevated Levels of Selenium Species in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients with Disease-Associated Gene Mutations. Neurodegenerative Diseases 17:171-180. DOI: 10.1159/000460253.
  5. Michalke B., Willkommen D., Drobyshev E., Solovyev N. 2017. The importance of speciation analysis in neurodegeneration research. TrAC – Trends in Analytical Chemistry, 10.1016/j.trac.2017.08.008. DOI: 10.1016/j.trac.2017.08.008.
  6. Shishov A., Gorbunov I., Bulatov A. 2017. Fast flow-based method for automated and miniaturized determination of ferrocene in gasoline. Microchemical Journal 130:185-190. DOI: 10.1016/j.microc.2016.09.006.
  7. Solovyev N., Vinceti M., Grill P., Mandrioli J., Michalke B. 2017. Redox speciation of iron, manganese, and copper in cerebrospinal fluid by strong cation exchange chromatography – sector field inductively coupled plasma mass spectrometry. Analytica Chimica Acta 973:25-33. DOI: 10.1016/j.aca.2017.03.040.
  8. Solovyev N.D., Fedoros E.I., Drobyshev E.J., Ivanenko N.B., Pigarev S.E., Tyndyk M.L., Anisimov V.N., Vilpan Y.A., Panchenko A.V. 2017. Anticancer activity and tissue distribution of platinum (II) complex with lignin-derived polymer of benzene-poly-carboxylic acids. Journal of Trace Elements in Medicine and Biology 43:72-79. DOI: 10.1016/j.jtemb.2016.11.009.
  9. Ganeev A.A., Gubal A.R., Potapov S.V., Agafonova N.N., Nemets V.M. 2016. Mass spectrometric methods for the direct elemental and isotopic analysis of solid materials. Russian Chemical Reviews 85:427-444. DOI: 10.1070/RCR4504.
  10. Iakovleva E., Maydannik P., Ivanova T.V., Sillanpää M., Tang W.Z., Mäkilä E., Salonen J., Gubal A., Ganeev A.A., Kamwilaisak K., Wang S. 2016. Modified and unmodified low-cost iron-containing solid wastes as adsorbents for efficient removal of As(III) and As(V) from mine water. Journal of Cleaner Production 133:1095-1104. DOI: 10.1016/j.jclepro.2016.05.147.
  11. Koryagina N.L., Savel’eva E.I., Karakashev G.V., Babakov V.N., Dubrovskii Y.A., Ukolova E.S., Khlebnikova N.S., Murashko E.A., Koneva V.Y., Ukolov A.I., Kopeikin V.A., Radilov A.S. 2016. Determination of protein adducts of organophosphorus nerve agents in blood plasma. Journal of Analytical Chemistry 71:849-859. DOI: 10.1134/S1061934816080086.
  12. Zubakina E.A., Solovyev N.D., Savinkova E.S., Slesar N.I. 2016. Sample preparation for cadmium quantification in sunflower (Heliánthus ánnuus) seeds using anodic stripping voltammetry. Analytical Methods 8:326-332. DOI: 10.1039/c5ay02275d.
  13. Ganeev A., Bogdanova O., Ivanov I., Burakov B., Agafonova N., Korotetski B., Gubal A., Solovyev N., Iakovleva E., Sillanpää M. 2015. Direct determination of uranium and thorium in minerals by time-of-flight mass spectrometry with pulsed glow discharge. RSC Advances 5:80901-80910. DOI: 10.1039/c5ra13312b.
  14. Navolotskii D.V., Ivanenko N.B., Solovyev N.D., Fedoros E.I., Panchenko A.V. 2015. Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP-C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry. Drug Testing and Analysis 7:737-744. DOI: 10.1002/dta.1824.
  15. Solovyev N.D. 2015. Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. Journal of Inorganic Biochemistry 153:1-12. DOI: 10.1016/j.jinorgbio.2015.09.003.
  16. Ivanenko N.B., Ivanenko A.A., Solovyev N.D., Navolotskii D.V., Pavlova O.V., Ganeev A.A. 2014. Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion. Biomeditsinskaya Khimiya 60:378-388.
  17. Ivanenko N.B., Solovyev N.D., Ivanenko A.A., Navolotskii D.V. 2014. Biological monitoring of arsenic pollution based on whole blood arsenic atomic absorption assessment with in situ hydride trapping. Journal of Analytical Atomic Spectrometry 29:1850-1857. DOI: 10.1039/c4ja00130c.
  18. Ganeev A.A., Gubal A.R., Potapov S.V., Pogarev S.E., Sholupov S.E., Uskov K.N., Ivanov I.S. 2013. Elimination of water interference in pulsed glow discharge time-of-flight mass spectrometry. Journal of Analytical Chemistry 68:1205-1211. DOI: 10.1134/S1061934813140050.
  19. Ivanenko N.B., Ivanenko A.A., Solovyev N.D., Zeimal A.E., Navolotskii D.V., Drobyshev E.J. 2013. Biomonitoring of 20 trace elements in blood and urine of occupationally exposed workers by sector field inductively coupled plasma mass spectrometry. Talanta 116:764-769. DOI: 10.1016/j.talanta.2013.07.079.
  20. Jiang W., Dubrovskii Y.A., Podolskaya E.P., Murashko E.A., Babakov V., Nachon F., Masson P., Schopfer L.M., Lockridge O. 2013. PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin. Chemical Research in Toxicology 26:1917-1925. DOI: 10.1021/tx400352h.
  21. Jiang W., Murashko E.A., Dubrovskii Y.A., Podolskaya E.P., Babakov V.N., Mikler J., Nachon F., Masson P., Schopfer L.M., Lockridge O. 2013. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase. Analytical Biochemistry 439:132-141. DOI: 10.1016/j.ab.2013.04.018.
  22. Solovyev N., Berthele A., Michalke B. 2013. Selenium speciation in paired serum and cerebrospinal fluid samples. Analytical and Bioanalytical Chemistry 405:1875-1884. DOI: 10.1007/s00216-012-6294-y.
  23. Vinceti M., Solovyev N., Mandrioli J., Crespi C.M., Bonvicini F., Arcolin E., Georgoulopoulou E., Michalke B. 2013. Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite. NeuroToxicology 38:25-32. DOI: 10.1016/j.neuro.2013.05.016.
  24. Dubrovskii Y.A., Gladilovich V.D., Krasnov I.A., Podolskaya E.P., Murashko E.A., Babakov V.N. 2012. Isolation of alkylated rat hemoglobin adducts using metal-affinity chromatography. Russian Journal of Bioorganic Chemistry 38:41-45. DOI: 10.1134/S1068162012010050.
  25. Ganeev A.A., Gubal A.R., Uskov K.N., Potapov S.V. 2012. Analytical glow discharge mass spectrometry. Russian Chemical Bulletin 61:752-767. DOI: 10.1007/s11172-012-0107-5.
  26. Ivanenko N.B., Solovyev N.D., Ivanenko A.A., Ganeev A.A. 2012. Application of zeeman graphite furnace atomic absorption spectrometry with high-frequency modulation polarization for the direct determination of aluminum, beryllium, cadmium, chromium, mercury, manganese, nickel, lead, and thallium in human blood. Archives of Environmental Contamination and Toxicology 63:299-308. DOI: 10.1007/s00244-012-9784-1.
  27. Shreiner E.V., Murashko E.A., Dubrovskii Y.A., Krasnov N.V., Podolskaya E.P., Babakov V.N. 2012. Identification of rat and human hemoglobin acetylation sites formed as a result of interaction with acetylsalicylic acid. Russian Journal of Bioorganic Chemistry 38:126-132. DOI: 10.1134/S1068162012020094.
  28. Vorob’ev-Desyatovskii N.V., Kubyshkin S.A., Ibragimova R.I., Kaichev V.V., Dubrovskii Y.A., Babakov V.N., Pichugina D.A. 2012. Study of sorption of platinum and palladium cyanometallate complexes as the key to understanding the mechanism of binding the [Au(CN)<inf>2</inf>]-anion with carbon adsorbents. Russian Journal of General Chemistry 82:384-397. DOI: 10.1134/S107036321203005X.
  29. Ganeev A.A., Gubal A.R., Mosichev V.I., Pershin N.V., Petrov S.N., Potapov S.V., Uskov K.N. 2011. Lumas-30 time-of-flight mass spectrometer with pulsed glow discharge for direct determination of nitrogen in steel. Journal of Analytical Chemistry 66:1411-1416. DOI: 10.1134/S1061934811140097.
  30. Ivanenko N.B., Ganeev A.A., Solovyev N.D., Moskvin L.N. 2011. Determination of trace elements in biological fluids. Journal of Analytical Chemistry 66:784-799. DOI: 10.1134/S1061934811090036.
  31. Solovyev N.D., Ivanenko N.B., Ivanenko A.A. 2011. Whole blood thallium determination by GFAAS with high-frequency modulation polarization Zeeman effect background correction. Biological Trace Element Research 143:591-599. DOI: 10.1007/s12011-010-8865-0.
  32. Ganeev A.A., Gubal A.R., Potapov S.V., Tyukal’tsev R.V. 2009. Time-of-flight mass spectrometry with pulsed gas-discharge ionization: Study of relative sensitivities of components. Journal of Analytical Chemistry 64:696-704. DOI: 10.1134/S1061934809070077.